| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Radiology (Drs. Guttmann, Warfield, and Wei, and M.C. Anderson), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA; the Departments of Neurology (Drs. Benson, Hall, Abu-Hasaballah, and Wolfson), and Community Medicine and Health Care (Dr. Hall), University of Connecticut Health Center; the Department of Statistics (Dr. Hall), University of Connecticut, Storrs, CT; and Departments of Radiology and Biomedical Engineering (Dr. Mugler), University of Virginia Health Sciences Center, Charlottesville, VA.
Address correspondence and reprint requests to Dr. Charles R.G. Guttmann, Department of Radiology, Brigham and Women’s Hospital, 221 Longwood Avenue, Boston, MA 02115; e-mail: guttmann{at}bwh.harvard.edu
OBJECTIVE: To investigate the relationship between white matter abnormalities and impairment of gait and balance in older persons.
METHODS: Quantitative MRI was used to evaluate the brain tissue compartments of 28 older individuals separated into normal and impaired groups on the basis of mobility performance testing using the Short Physical Performance Battery. In addition, individuals were tested on six indices of gait and balance. For imaging data, segmentation of intracranial volume into four tissue classes was performed using template-driven segmentation, in which signal-intensity–based statistical tissue classification is refined using a digital brain atlas as anatomic template.
RESULTS: Both decreased white matter volume, which was age-related, and increased white matter signal abnormalities, which were not age-related, were observed in the mobility-impaired group compared with the control subjects. The average volume of white matter signal abnormalities for impaired individuals was nearly double that of control subjects.
CONCLUSIONS: This cross-sectional study suggests that decreased white matter volume is age-related, whereas increased white matter signal abnormalities are most likely to occur as a result of disease. Both of these changes are independently associated with impaired mobility in older persons and therefore likely to be additive factors of motor disability.
Key words: Aging—Brain—Gait—Balance—White matter—MRI—Image processing.
This article has been cited by other articles:
|
|
 |
|
  C Blahak, H Baezner, L Pantoni, A Poggesi, H Chabriat, T Erkinjuntti, F Fazekas, J M Ferro, P Langhorne, J O'Brien, et al. Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study J. Neurol. Neurosurg. Psychiatry, June 1, 2009; 80(6): 608 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Srikanth, R. Beare, L. Blizzard, T. Phan, J. Stapleton, J. Chen, M. Callisaya, K. Martin, and D. Reutens Cerebral White Matter Lesions, Gait, and the Risk of Incident Falls: A Prospective Population-Based Study Stroke, January 1, 2009; 40(1): 175 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rosano, H. Aizenstein, J. Brach, A. Longenberger, S. Studenski, and A. B. Newman Special Article: Gait Measures Indicate Underlying Focal Gray Matter Atrophy in the Brain of Older Adults J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2008; 63(12): 1380 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pantoni Leukoaraiosis: From an Ancient Term to an Actual Marker of Poor Prognosis Stroke, May 1, 2008; 39(5): 1401 - 1403. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Baezner, C. Blahak, A. Poggesi, L. Pantoni, D. Inzitari, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. M. Ferro, P. Langhorne, et al. Association of gait and balance disorders with age-related white matter changes: The LADIS Study Neurology, March 18, 2008; 70(12): 935 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Functional Outcomes for Clinical Trials in Frail Older Persons: Time To Be Moving: Working Group on Functional Outcome Measures for Clinical Trials J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2008; 63(2): 160 - 164. [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Corti, G. Baggio, L. Sartori, G. Barbato, E. Manzato, E. Musacchio, L. Ferrucci, G. Cardinali, D. Donato, L. J. Launer, et al. White Matter Lesions and the Risk of Incident Hip Fracture in Older Persons: Results From the Progetto Veneto Anziani Study Arch Intern Med, September 10, 2007; 167(16): 1745 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Nave, S. Foresti, A. Pratesi, A. Ginestroni, M. Inzitari, E. Salvadori, M. Giannelli, S. Diciotti, D. Inzitari, and M. Mascalchi Whole-Brain Histogram and Voxel-Based Analyses of Diffusion Tensor Imaging in Patients with Leukoaraiosis: Correlation with Motor and Cognitive Impairment AJNR Am. J. Neuroradiol., August 1, 2007; 28(7): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soumare, A. Elbaz, V. Ducros, B. Tavernier, A. Alperovitch, and C. Tzourio Cross-sectional association between homocysteine and motor function in the elderly. Neurology, September 26, 2006; 67(6): 985 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Elbaz, M. Ripert, B. Tavernier, B. Fevrier, M. Zureik, J. Gariepy, A. Alperovitch, and C. Tzourio Common Carotid Artery Intima-Media Thickness, Carotid Plaques, and Walking Speed Stroke, October 1, 2005; 36(10): 2198 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P S Sachdev, W Wen, H Christensen, and A F Jorm White matter hyperintensities are related to physical disability and poor motor function J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 362 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Kuo and L. A. Lipsitz Cerebral White Matter Changes and Geriatric Syndromes: Is There a Link? J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2004; 59(8): M818 - M826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M Starr, S A Leaper, A D Murray, H A Lemmon, R T Staff, I J Deary, and L J Whalley Brain white matter lesions detected by magnetic resosnance imaging are associated with balance and gait speed J. Neurol. Neurosurg. Psychiatry, January 1, 2003; 74(1): 94 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. Cook, A. F. Leuchter, M. L. Morgan, E. W. Conlee, S. David, R. Lufkin, A. Babaie, J. J. Dunkin, R. O'Hara, S. Simon, et al. Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects Arch Neurol, October 1, 2002; 59(10): 1612 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Miller, F. Barkhof, J. A. Frank, G. J. M. Parker, and A. J. Thompson Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance Brain, August 1, 2002; 125(8): 1676 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Benson, C. R.G. Guttmann, X. Wei, S. K. Warfield, C. Hall, J. A. Schmidt, R. Kikinis, and L. I. Wolfson Older people with impaired mobility have specific loci of periventricular abnormality on MRI Neurology, January 8, 2002; 58(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Whitman, T. Tang, A. Lin, and R. W. Baloh A prospective study of cerebral white matter abnormalities in older people with gait dysfunction Neurology, September 25, 2001; 57(6): 990 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wolfson Gait and Balance Dysfunction: A Model of the Interaction of Age and Disease Neuroscientist, April 1, 2001; 7(2): 178 - 183. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
