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From the Institute for the Health of the Elderly (Drs. Barber, Ballard, McKeith, and O’Brien), and the Department of Neuroradiology (Dr. Gholkar), Newcastle General Hospital, Newcastle upon Tyne, UK.
Address correspondence and reprint requests to Dr. R. Barber, Institute for the Health of the Elderly, Westgate Road, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK; e-mail: robert.barber{at}ncl.ac.uk
OBJECTIVE: To compare global and regional atrophy on MRI in subjects with dementia with Lewy bodies (DLB), AD, vascular dementia (VaD), and normal aging. In addition, the relationship between APOE-
4 genotype and volumetric indices was examined.
METHOD: MRI-based volume measurements of the whole-brain, ventricles, frontal lobe, temporal lobe, hippocampus, and amygdala were acquired in elderly subjects with DLB (n = 27; mean age = 75.9 years), AD (n = 25; 77.2 years), VaD (n = 24; 76.9 years), and normal control subjects (n = 26; 76.2 years).
RESULTS: Subjects with DLB had significantly larger temporal lobe, hippocampal, and amygdala volumes than those with AD. No significant volumetric difference between subjects with DLB and VaD was observed. Compared with control subjects, ventricular volumes were increased in all patients with dementia, though those with DLB showed a relative preservation of whole-brain volume. There were no significant differences in frontal lobe volumes between the four groups. APOE-4 status was not associated with volumetric indices.
CONCLUSION: The findings support the hypothesis that DLB is associated with a relative preservation of temporal lobe structures. In the differentiation of DLB and AD, this may have important implications for diagnosis.
Key words: Dementia with Lewy bodies—Alzheimer’s disease—Vascular dementia—MRI—Temporal lobe—Frontal lobe.
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