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From the Department of Neurology (Drs. Earley and Allen), Johns Hopkins School of Medicine, Baltimore, MD; the Department of Neuroscience and Anatomy (Drs. Connor, Malecki, and Epstein), Milton S. Hersey Medical Center, Pennsylvania State University; and the Department of Nutrition (Dr. Beard), University Park, Pennsylvania State University, State College.
Address correspondence and reprint requests to Dr. Christopher J. Earley, Johns Hopkins Bayview Medical Center, Department of Neurology, 4940 Eastern Avenue, A6C, Room 678, Baltimore, MD 21224; e-mail: cward{at}jhmi.edu
CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.
Key words: Restless legs syndrome—Iron—Ferritin—Transferrin—CSF.
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