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Neurology 2000;54:1859-1861
© 2000 American Academy of Neurology
Brief Communications

Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS

S. L. Hauser, MD, J. R. Oksenberg, PhD, R. Lincoln, BS, J. Garovoy, BA, R. W. Beck, MD, PhD, S. R. Cole, PhD, P. S. Moke, MSPH, K. E. Kip, PhD, R. L. Gal, MSPH, D. T. Long, MSPH and the Optic Neuritis Study Group

From the Department of Neurology (Drs. Hauser and Oksenberg, and R. Lincoln and J. Garovoy), University of California, San Francisco, CA; and the Jaeb Center for Health Research (Drs. Beck, Cole, and Kip, and P. Moke, R. Gal, and D. Long), Tampa, FL.

Address correspondence and reprint requests to Dr. Roy W. Beck, Jaeb Center for Health Research, 3010 E. 138th Avenue, Suite 9, Tampa, FL 33613; e-mail: rbeck{at}jaeb.org

The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.

Key words: Multiple sclerosis—Optic neuritis—Human leukocyte antigen




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