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Neurology 2000;55:122-125
© 2000 American Academy of Neurology
Brief Communications

Ictal SPECT during autonomic crisis in familial dysautonomia

Felicia B. Axelrod, MD, Mary Zupanc, MD, Max J. Hilz, MD, PhD and Elissa L. Kramer, MD

From the Departments of Pediatrics (Dr. Axelrod) and Neurology (Drs. Axelrod and Hilz), and the Division of Nuclear Medicine, Department of Radiology (Dr. Kramer), New York University School of Medicine; and the Departments of Pediatrics and Neurology (Dr. Zupanc), Columbia University School of Medicine, New York, NY.

Address correspondence and reprint requests to Dr. Felicia B. Axelrod, New York University School of Medicine, 530 First Avenue, Suite 9Q, New York, NY 10016.

The authors report results of SPECT cerebral perfusion studies in two patients with familial dysautonomia (FD) during dysautonomic crises and when clinically stable. SPECT imaging studies used 99mTc ethylene cysteine dimer. During dysautonomic crises, regions in the temporoparietal and frontal lobes had increased uptake. Uptake in these areas was less during asymptomatic periods. Episodic asymmetric cerebral perfusion during crises especially affecting the frontal and temporal lobes is suggestive of ictal activity.




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F. B. Axelrod and D. Berlin
Pregabalin: A New Approach to Treatment of the Dysautonomic Crisis
Pediatrics, August 1, 2009; 124(2): 743 - 746.
[Abstract] [Full Text] [PDF]


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