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From the Departments of Internal Medicine (Dr. Lichtman) and Neurology (Dr. Seliger), Helen Hayes Hospital, West Haverstraw, NY; and the Departments of Neurology (Drs. Seliger and Marder), Internal Medicine (Dr. Lichtman), and Pathology (Dr. Tycko), and the Sergievsky Center and Taub Institute (Dr. Marder), Columbia University College of Physicians and Surgeons, New York.
Address correspondence and reprint requests to Dr. Steven W. Lichtman, Department of Internal Medicine, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993; e-mail: lichtman{at}helenhayeshosp.org
OBJECTIVE: APOE 
4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles.
METHODS: Thirty-one patients with head injury who had completed the Acute Neurorehabilitation Program at Helen Hayes Hospital were evaluated for presence of APOE 4 and assessed for recovery based on Functional Independence Measures (FIM).
RESULTS: Analysis of covariance (using coma days as the covariate to control for differences in initial severity of injury between subjects with and without APOE 4) revealed a significant difference for both total FIM and motor FIM scores between the subjects with and without APOE 4. Specifically, there were lower scores for total FIM (df = 30; F = 3.341; p = 0.05) and motor FIM (df = 30; F = 4.189; p = 0.026) in APOE 4 carriers. No difference was found for the cognitive portion of the FIM.
CONCLUSIONS: The data suggest that the presence of the lipoprotein APOE 4 adversely affects rehabilitation outcome for traumatic brain injury survivors.–1539
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|
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