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Neurology 2000;55:1572-1575
© 2000 American Academy of Neurology
Brief Communications

Menstrual-related changes in motoric function in women with Parkinson’s disease

K. Kompoliti, MD, C. L. Comella, MD, J. A. Jaglin, RN, S. Leurgans, PhD, R. Raman, MS and C. G. Goetz, MD

From the Departments of Neurological Sciences (Drs. Kompoliti, Comella, Goetz, and J.A. Jaglin) and Preventive Medicine (Dr. Leurgans and R. Raman), Rush–Presbyterian–St Luke’s Medical Center, Rush University, Chicago, IL.

Address correspondence and reprint requests to Dr. Katie Kompoliti, Department of Neurological Science, Section of Movement Disorders, 1725 W. Harrison Street, Suite 755, Chicago, IL 60612; e-mail: kkompoli{at}rush.edu

Questionnaire studies have found that parkinsonism worsens in women during the premenstrual period, when estrogen and progesterone levels are presumably at their nadir. To assess this patient-based observation and correlate motor signs with hormonal levels, the authors prospectively studied 10 menstruating women with PD in their "off" state, on 5 successive weeks. Although PD severity fluctuated during the study period, there was no significant correlation between the objective or subjective measures of parkinsonism and estrogen and progesterone levels.–1574




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 Arch NeurolHome page
L. J. Currie, M. B. Harrison, J. M. Trugman, J. P. Bennett, and G. F. Wooten
Postmenopausal Estrogen Use Affects Risk for Parkinson Disease
Arch Neurol, June 1, 2004; 61(6): 886 - 888.
[Abstract] [Full Text] [PDF]


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