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¹⁸F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

From the Department of Geriatric Medicine (Drs. Hu, Okamura, Arai, Higuchi, Matsui, Tashiro, Shinkawa, and Sasaki), Tohoku University School of Medicine, and the Cyclotron and Radioisotope Center (Drs. Itoh and Ido), Tohoku University, Sendai, Miyagi, Japan.

Address correspondence and reprint requests to Dr. Hiroyuki Arai, Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980-8574, Japan.

Using ¹⁸F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with ¹⁸F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.–1576

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