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From the Departments of Neurology and Pathology, Division of Neuropathology (Dr. Morris), the Division of Biostatistics (J. Baty), the Department of Medicine, Division of Geriatrics and Gerontology (Dr. Carr), and the Alzheimer’s Disease Research Center (Dr. Morris), Washington University School of Medicine, St. Louis, MO; and the Division of Family Medicine (Dr. Gray), Valley Medical Center, Renton, WA.
Address correspondence and reprint requests to Dr. David B. Carr, Alzheimer’s Disease Research Center, Campus Box 8111-ADRC, Washington University School of Medicine, 4488 Forest Park Blvd., St. Louis, MO 63108.
Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in controls) later development of dementia. In contrast, informant-reported memory loss distinguished nondemented from demented individuals and predicted future diagnosis of DAT.
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