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 Volume 55, Number 12, December 26, 2000
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Neurology 2000;55:1841-1846
© 2000 American Academy of Neurology
Articles

Ross syndrome plus

Beyond Horner, Holmes–Adie, and harlequin

R. K. Shin, MD;, S. L. Galetta, MD;, T. Y. Ting, MD;, K. Armstrong, MD; and S. J. Bird, MD

From the Departments of Neurology (Drs. Shin, Galetta, Ting, and Bird) and Internal Medicine (Dr. Armstrong), Hospital of the University of Pennsylvania, Philadelphia.

Address correspondence and reprint requests to Dr. Robert K. Shin, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283; e-mail: shirobk{at}mail.med.upenn.edu

BACKGROUND: Ross syndrome is an uncommon disorder characterized by the triad of segmental anhidrosis, hyporeflexia, and tonic pupils.

METHODS: The authors describe the clinical findings of five patients with Ross syndrome and detail the results of their pharmacologic and autonomic testing.

RESULTS: In four patients, the classic findings of Ross syndrome were accompanied by Horner’s syndrome. Other symptoms of dysautonomia were also common.

CONCLUSIONS: These findings suggest that Ross syndrome is a dysautonomic condition of varying expression resulting from a generalized injury to ganglion cells or their projections.




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