Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alvarado–de la Barrera, C.
Right arrow Articles by Llorente, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alvarado–de la Barrera, C.
Right arrow Articles by Llorente, L.
Neurology 2000;55:1897-1900
© 2000 American Academy of Neurology
Brief Communication

HLA class II genotypes in Mexican Mestizos with familial and nonfamilial multiple sclerosis

C. Alvarado–de la Barrera, PhD, J. Zúñiga–Ramos, PhD, J. A. Ruíz–Morales, MD, B. Estañol, MD, J. Granados, MD and L. Llorente, MD

From the Departments of Immunology and Rheumatology (Drs. Alvarado–de la Barrera, Zúñiga–Ramos, Ruíz–Morales, Granados, and Llorente) and Neurology (Dr. Estañol), Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México.

Address correspondence and reprint requests to Dr. Luis Llorente, Departamento de Inmunología y Reumatología, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan 14000, México DF; e-mail: lllyrp{at}quetzal.innsz.mx

Predisposition to MS is associated with the HLA-DR2 antigen in white patients. The authors investigated the genetic factors behind the increasing frequency of MS in the Mexican population. HLA-DR and DQ were analyzed in 17 patients with MS, 15 of their first-degree relatives, and 99 healthy ethnically matched controls. DR2 or DR3 was found in 15 of 17 patients. In controls, both alleles had frequencies less than 0.05. MS in Mexican patients was associated with HLA-DR2 and DR3.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. Mangalam, D. Luckey, E. Basal, M. Jackson, M. Smart, M. Rodriguez, and C. David
HLA-DQ8 (DQB1*0302)-Restricted Th17 Cells Exacerbate Experimental Autoimmune Encephalomyelitis in HLA-DR3-Transgenic Mice
J. Immunol., April 15, 2009; 182(8): 5131 - 5139.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
M Osoegawa, J Kira, T Fukazawa, K Fujihara, S Kikuchi, M Matsui, T Kohriyama, G Sobue, T Yamamura, Y Itoyama, et al.
Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years
Multiple Sclerosis, February 1, 2009; 15(2): 159 - 173.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
A. Mangalam, D. Luckey, E. Basal, M. Behrens, M. Rodriguez, and C. David
HLA-DQ6 (DQB1*0601)-Restricted T Cells Protect against Experimental Autoimmune Encephalomyelitis in HLA-DR3.DQ6 Double-Transgenic Mice by Generating Anti-Inflammatory IFN-{gamma}
J. Immunol., June 1, 2008; 180(11): 7747 - 7756.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
H. Schmidt, D. Williamson, and A. Ashley-Koch
HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review
Am. J. Epidemiol., May 15, 2007; 165(10): 1097 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
V. M. Rivera
The Terms Latino and Anglo and Tendency to Early Alzheimer Disease
Arch Neurol, November 1, 2005; 62(11): 1787 - 1787.
[Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. A. Dyment, B. M. Herrera, M. Z. Cader, C. J. Willer, M. R. Lincoln, A. D. Sadovnick, N. Risch, and G. C. Ebers
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
Hum. Mol. Genet., July 15, 2005; 14(14): 2019 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J M Greer and M P Pender
The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DR{beta}1 chain is associated with the clinical course of multiple sclerosis
J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 656 - 662.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Khare, M. Rodriguez, and C. S. David
HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis
Int. Immunol., April 1, 2003; 15(4): 535 - 546.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
J A Simon, J Granados, J Cabiedes, J R. Morales, and J A. Varela
Clinical and immunogenetic characterization of Mexican patients with 'Rhupus'
Lupus, May 1, 2002; 11(5): 287 - 292.
[Abstract] [PDF]

Home page
 Hum Mol GenetHome page
M. G. Marrosu, R. Murru, M. R. Murru, G. Costa, P. Zavattari, M. Whalen, E. Cocco, C. Mancosu, L. Schirru, E. Solla, et al.
Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia
Hum. Mol. Genet., December 1, 2001; 10(25): 2907 - 2916.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
V. M. Rivera, J. A. Cabrera, S. Mirsattari, and C. Power
Aboriginals with multiple sclerosis: HLA types and predominance of neuromyelitis optica
Neurology, September 11, 2001; 57(5): 937 - 938.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by AAN Enterprises, Inc.