Neurology
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Neurology 2000;55:1913-1917
© 2000 American Academy of Neurology
Brief Communications

Adeno-associated virus in normal and myositis human skeletal muscle

Z Tezak, PhD, K. Nagaraju, DVM, PhD, P. Plotz, MD and E. P. Hoffman, PhD

From the Research Center for Genetic Medicine (Drs. Tezak and Hoffman), Children’s National Medical Center, Washington, DC; Arthritis and Rheumatism Branch (Drs. Nagaraju and Plotz), National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD; and the Department of Molecular Genetics and Biochemistry (Drs. Tezak and Hoffman), University of Pittsburgh School of Medicine, PA.

Address correspondence and reprint requests to Dr. Eric P. Hoffman, Research Center for Genetic Medicine, Children’s National Medical Center, George Washington University, 111 Michigan Ave. NW, Washington, DC 20010; e-mail: ehoffman{at}cnmc.org

The normal tissue tropism of adeno-associated virus (AAV) is poorly defined, although the majority of humans test seropositive for this virus. Eighty-five muscle biopsy specimens were tested for AAV genomes; AAV DNA was identified in 17% of normal and 10% of Duchenne muscular dystrophy muscle biopsy specimens, but in only 3% of peripheral blood samples. AAV genomes were absent from all 37 muscle biopsy specimens from patients with myositis tested. Muscle is a major target organ for AAV, and infection is associated with autoimmune disease of muscle.






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