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Neurology 2000;55:1921-1923
© 2000 American Academy of Neurology
Brief Communications

Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson’s disease

V. Fraix, MD;, P. Pollak, MD;, N. Van Blercom, MD;, J. Xie, MD;, P. Krack, MD;, A. Koudsie, MD; and A.L. Benabid, MD, PhD

From the Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University, France; and Neurology Department (Dr. Krack), Christian Albrecht Universität, Kiel, Germany.

Address correspondence and reprint requests to Dr. Pierre Pollak, Department of Clinical and Biological Neurosciences, Joseph Fourier University, B.P. 217, 38043 Grenoble Cedex 9, France; e-mail: pierre.pollak{at}ujf-grenoble.fr

Article abstract—The authors studied the effect of bilateral subthalamic nucleus stimulation on levodopa-induced dyskinesias in 24 consecutive parkinsonian patients with disabling dyskinesias. The improvement in the three subtypes of levodopa-induced dyskinesias was significant from the third postoperative month and was mainly due to the decrease in the daily dose of levodopa allowed by the stimulation-induced improvement in the motor score.




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