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PET shows that striatal dopamine D1 and D2 receptors are differentially affected in AD

From the Department of Neurology (Drs. Kemppainen, Ruottinen, and Rinne), University of Turku; and the Radiochemistry Laboratory (Dr. Någren), Turku PET Centre (Dr. Rinne), Finland.

Address correspondence and reprint requests to Dr. Juha O. Rinne, Department of Neurology, University of Turku, FIN-20520 Turku, Finland; e-mail: juha.rinne{at}pet.tyks.fi

OBJECTIVE: To study dopamine D1 and D2 receptors in the putamen and the caudate nucleus in patients with AD and age-matched healthy controls by means of PET.

METHODS: A dopamine D1 receptor antagonist ([¹¹C]NNC 756) and a D2 receptor antagonist ([¹¹C]raclopride) were used as ligands. The uptake of these ligands was calculated as a distribution volume ratio of the putamen and the caudate nucleus to the cerebellum.

RESULTS: The mean [¹¹C]NNC 756 uptake in AD was reduced by 14% from the mean control value both in the putamen (p = 0.004) and the caudate nucleus (p = 0.009). There was no significant reduction in the mean [¹¹C]raclopride uptake in either the putamen or the caudate nucleus in AD. There was no correlation between [¹¹C]NNC 756 or [¹¹C]raclopride uptake and Mini-Mental State Examination or motor Unified PD Rating Scale scores in patients with AD.

CONCLUSIONS: There are changes in striatal D1 but not in D2 receptors in AD.

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