Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamada, H.
Right arrow Articles by Itoh, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamada, H.
Right arrow Articles by Itoh, H.
Neurology 2000;55:218-223
© 2000 American Academy of Neurology
Articles

A milestone for normal development of the infantile brain detected by functional MRI

H. Yamada, MD, N. Sadato, MD, Y. Konishi, MD, S. Muramoto, MD, K. Kimura, MD, M. Tanaka, RT, Y. Yonekura, MD, Y. Ishii, MD and H. Itoh, MD

From the Department of Radiology (Drs. Yamada, Muramoto, Ishii, and Itoh, and M. Tanaka), Department of Pediatrics (Dr. Kimura), and Biomedical Imaging Research Center (Dr. Yonekura), Fukui Medical University, Fukui; Psychophysiology Section (Dr. Sadato), Department of Cerebral Research, National Institute for Physiological Sciences, Okazaki; and Department of Pediatrics (Dr. Konishi), Saitama Medical School, Saitama, Japan.

Address correspondence and reprint requests to Dr. Hiroki Yamada, Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui, 910-11, Japan; e-mail: yamadahi{at}fmsrsa.fukui-med.ac.jp

OBJECTIVE: To investigate the relationship between cerebral cortical function and white matter myelination in the visual pathway in the evaluation of normal brain development.

METHODS: The authors performed quantitative analysis of white matter myelination detected with conventional T1-weighted spin echo (SE) MRI and brain functional MRI (fMRI) using echoplanar imaging with photic stimulation in 27 neurologically normal infants (age range, 0 to 22 weeks).

RESULTS: An age-dependent gradual increase in signal intensity was observed in optic radiation on the T1-weighted SE images, indicating progression of white matter myelination. A rapid age-dependent reverse in signal response was observed on fMRI. Infants older than 8 weeks showed a stimulus-induced signal decrease in the visual cortex, whereas infants younger than 7 weeks showed a signal increase.

CONCLUSIONS: A rapid inversion of response revealed by fMRI with photic stimulation in infants suggests a change in oxygen consumption during neuronal activation, which is related to rapid synapse formation and accompanying increased metabolism. fMRI can detect dynamic metabolic changes during brain maturation, which is a different developmental process from white matter myelination. The metabolic changes detected by fMRI provide a milestone for the evaluation of normal brain development.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
J. M. Pascual, D. Wang, V. Hinton, K. Engelstad, C. M. Saxena, R. L. Van Heertum, and D. C. De Vivo
Brain Glucose Supply and the Syndrome of Infantile Neuroglycopenia
Arch Neurol, April 1, 2007; 64(4): 507 - 513.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
I. Valencia, C. Fons, S. V. Kothare, D. S. Khurana, S. Yum, H. H. Hardison, and A. Legido
Efficacy and Tolerability of Topiramate in Children Younger Than 2 Years Old
J Child Neurol, August 1, 2005; 20(8): 667 - 670.
[Abstract] [PDF]

Home page
 Pediatr. Rev.Home page
A. N. Schore
Back to Basics: Attachment, Affect Regulation, and the Developing Right Brain: Linking Developmental Neuroscience to Pediatrics
Pediatr. Rev., June 1, 2005; 26(6): 204 - 217.
[Full Text] [PDF]

Home page
 PediatricsHome page
D. A. Christakis, F. J. Zimmerman, D. L. DiGiuseppe, and C. A. McCarty
Early Television Exposure and Subsequent Attentional Problems in Children
Pediatrics, April 1, 2004; 113(4): 708 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Taga, K. Asakawa, A. Maki, Y. Konishi, and H. Koizumi
Brain imaging in awake infants by near-infrared optical topography
PNAS, September 16, 2003; 100(19): 10722 - 10727.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. Haginoya, M. Munakata, R. Kato, H. Yokoyama, M. Ishizuka, and K. Iinuma
Ictal cerebral haemodynamics of childhood epilepsy measured with near-infrared spectrophotometry
Brain, September 1, 2002; 125(9): 1960 - 1971.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. Yamauchi, H. Okazawa, Y. Kishibe, K. Sugimoto, and M. Takahashi
Changes in Blood Flow and Oxygen Metabolism During Visual Stimulation in Carotid Artery Disease: Effect of Baseline Perfusion and Oxygen Metabolism
Stroke, May 1, 2002; 33(5): 1294 - 1300.
[Abstract] [Full Text] [PDF]