Neurology 2000;55:302-304
© 2000 American Academy of Neurology
Brief Communications
Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies
P. F. Chinnery, MRCP,
G. A. Taylor, BSc,
N. Howell, PhD,
R. M. Andrews, FRCOpth,
C. M. Morris, PhD,
R. W. Taylor, PhD,
I. G. McKeith, FRCPsych,
R. H. Perry, FRCPath,
J. A. Edwardson, PhD and
D. M. Turnbull, FRCP
From the Department of Neurology (P.F. Chinnery, G.A. Taylor, R.M. Andrews, R.W. Taylor, and D.M. Turnbull), The University of Newcastle upon Tyne; the Institute for the Health of the Elderly (G.A. Taylor, Dr. Morris, I.G. McKeith, R.H. Perry, and Dr. Edwardson), Newcastle General Hospital, Newcastle upon Tyne, UK; and the Biology Division (Dr. Howell), Department of Radiation Oncology, The University of Texas Medical Branch, Galveston.
Address correspondence and reprint requests to D.M. Turnbull, Department of Neurology, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.
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