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Optical intrinsic signal imaging in a rodent seizure model

From the Laboratory of NeuroImaging, Division of Brain Mapping, Department of Neurology, School of Medicine, University of California at Los Angeles.

Address correspondence and reprint requests to Dr. Arthur W. Toga, Laboratory of NeuroImaging, 710 Westwood Plaza, Room 4-238, Los Angeles, CA 90024-1769; e-mail: toga{at}loni.ucla.edu

The authors studied seizure activity with optical intrinsic signal (OIS) imaging in a rat seizure model. OIS, which measures vascular and metabolic effects associated with neuronal activity, showed significant cortical reflectance changes from penicillin-induced seizures, and correlated well with EEG epileptiform discharges. Furthermore, OIS changes often preceded initial EEG spikes. These observations suggest that OIS is well coupled with seizure activity, and may provide sensitive cues for seizure detection.

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