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Neurology 2000;55:440-442
© 2000 American Academy of Neurology
Brief Communications

AIDS myelopathy is not associated with elevated HIV viral load in cerebrospinal fluid

A. Geraci, MD, A. Di Rocco, MD, M. Liu, BS, P. Werner, PhD, M. Tagliati, MD, J. Godbold, PhD, D. Simpson, MD and S. Morgello, MD

From the Albert Einstein College of Medicine and Beth Israel Medical Center (Drs. Geraci, Di Rocco, Werner and Tagliati), Mount Sinai School of Medicine (Drs. Godbold, Simpson, Morgello and Ms. Liu), New York, NY.

Address correspondence and reprint requests to Dr. Alessandro Di Rocco, Department of Neurology, Beth Israel Medical Center, Phillips Ambulatory Care Center, 10 Union Square East, Suite 2R, New York, NY 10003.

The pathogenesis of AIDS-associated myelopathy is unknown. Elevated HIV-1 viral load in CSF has been associated with cognitive impairment. The authors investigated if a similar association exists in patients with myelopathy. The authors evaluated levels of HIV-1 RNA in the CSF of 16 individuals with AIDS myelopathy and in 16 nonmyelopathic HIV-infected control subjects. There was no correlation between levels of HIV-1 RNA and the presence or severity of myelopathy.




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A. Di Rocco, P. Werner, T. Bottiglieri, J. Godbold, M. Liu, M. Tagliati, A. Scarano, and D. Simpson
Treatment of AIDS-associated myelopathy with L-methionine: A placebo-controlled study
Neurology, October 12, 2004; 63(7): 1270 - 1275.
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