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Neurology 2000;55:593-595
© 2000 American Academy of Neurology
Brief Communications

Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD

O. Combarros, MD, M. Sánchez–Guerra, MD, J. Llorca, MD, A. Alvarez–Arcaya, MD, J. Berciano, MD, N. Peña, MD and C. Fernández–Viadero, MD

From the Service of Neurology (Drs. Combarros, Sánchez–Guerra, Alvarez–Arcaya, and Berciano), University Hospital "Marqués de Valdecilla"; Division of Preventive Medicine (Dr. Llorca), University of Cantabria School of Medicine, Santander; RTE Santander (Drs. Peña and Fernández–Viadero), Consejería de Sanidad, Cantabria, Spain.

Address correspondence and reprint requests to Dr. Combarros, Service of Neurology, University Hospital "Marqués de Valdecilla", 39008 Santander, Spain; e-mail: neuro{at}humv.es

An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.




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