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From the Department of Neurology (Drs. Hutchinson, Dhawan, and Eidelberg), New York University School of Medicine, New York; the Functional Brain Imaging Laboratory (Drs. Nakamura, Antonini, Belakhlef, Dhawan, and Eidelberg), North Shore University Hospital, Manhasset; and the Department of Psychiatry (Dr. Moeller), Columbia University, New York, NY.
Address correspondence and reprint requests to Dr. David Eidelberg, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030; e-mail: david1{at}nshs.edu
OBJECTIVE: To determine the metabolic topography of essential blepharospasm (EB).
BACKGROUND: EB is a cranial dystonia of unknown etiology and anatomic localization. The authors have used 18F-fluorodeoxyglucose (FDG) and PET with network analysis to identify distinctive patterns of regional metabolic abnormality associated with idiopathic torsion dystonia (ITD), as well as sleep induction during PET imaging to suppress involuntary movements, thereby reducing this potential confound in the analysis.
METHODS: Six patients with EB and six normal volunteers were scanned with FDG-PET. Scans were performed twice: once in wakefulness and once following sleep induction. The authors used statistical parametric mapping to compare glucose metabolism between patients with EB and control subjects in each condition. They also quantified the expression of the previously identified ITD-related metabolic networks in each subject in both conditions.
RESULTS: With active involuntary movements during wakefulness, the EB group exhibited hypermetabolism of the cerebellum and pons. With movement suppression during sleep, the EB group exhibited superior-medial frontal hypometabolism in a region associated with cortical control of eyelid movement. Network analysis demonstrated a specific metabolic covariance pattern associated with ITD was also expressed in the patients with EB in both the sleep and wake conditions.
CONCLUSION: These findings suggest that the clinical manifestations of EB are associated with abnormal metabolic activity in the pons and cerebellum, whereas the functional substrate of the disorder may be associated with abnormalities in cortical eyelid control regions. Furthermore, ITD-related networks are expressed in patients with EB, suggesting a functional commonality between both forms of primary dystonia.
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