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Neurology 2000;55:718-721
© 2000 American Academy of Neurology
Brief Communications

Creutzfeldt–Jakob disease associated with cadaveric dura mater grafts in Japan

K. Hoshi, MD, H. Yoshino, MD, J. Urata, MD, Y. Nakamura, MD, MPD, H. Yanagawa, MD, PhD and T. Sato, MD, PhD

From the Japanese National CJD Surveillance Group (Drs. Hoshi, Yoshino, Urata, Nakamura, Yanagawa, and Sato), Department of Neurology (Drs. Hoshi, Yoshino, Urata, and Sato), Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba-ken; and the Department of Public Health (Drs. Nakamura and Yanagawa), Jichi Medical School, Tochigi-ken, Japan.

Address correspondence and reprint requests to Dr. Takeshi Sato, 2-9-22 Naka, Kunitachi-Shi, Tokyo 186-0206, Japan.

A nationwide survey and recent information documented 57 patients with Creutzfeldt–Jakob disease (CJD) who had received dura mater grafts during the period between January 1979 and September 1999. At least 54 of these 57 patients received the same brand of dura mater graft from the same processor. Mean age at disease onset in the 57 patients with dural grafts was younger (51.9 years) than that in patients with sporadic CJD (63 years) (p < 0.0001). Initial symptoms were cerebellar ataxia, disorientation, and visual or oculomotor disturbance.




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