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From the Departments of Neurology (S. Sinha and Dr. Naritoku) and Pharmacology (Dr. Naritoku), Southern Illinois University, Springfield.
Address correspondence and reprint requests to Dr. Dean K. Naritoku, Department of Neurology, Southern Illinois University, PO Box 19637, Springfield, IL 62794-9637; e-mail: dnaritoku{at}siumed.edu
The authors reviewed hospital records of 13 patients with status epilepticus and hypotension who received IV valproate therapy. Most patients were elderly (74.4 ± 12.5 [SD] years) and received a loading dose of valproate of 25.1 ± 5.0 mg/kg (range 14.7 to 32.7), at a rate of 36.6 ± 25.1 mg/min (range 6.3 to 100). There were no significant changes in blood pressure, pulse, or use of vasopressors. The data suggest that valproate loading is well tolerated, even in patients with cardiovascular instability.
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