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Failure of long-term pallidal stimulation corrected by subthalamic stimulation in PD

From the Centre d’Investigation Clinique, Fédération de Neurologie and INSERM 289 (Drs. Agid, Bejjani, Bonnet, Damier, Houeto, and Staedler), Service d’Explorations Fonctionnelles Neurologiques (Dr. Pidoux), Service de Neuroradiologie (Dr. Dormont), and Service de Neurochirurgie (Dr. Cornu), Hôpital de la Salpêtrière, Paris, France; and Unité des troubles du movement (Dr. Bejjani), Hôpital Notre-Dame de Secours, Byblos, Lebanon.

Address correspondence and reprint requests to Dr. Y. Agid, Centre d’Investigation Clinique, Hôpital de la Salpêtrière, 47 Boulevard de l’Hôpital, 75013 Paris, France; e-mail: agid{at}ccr.jussieu.fr

Bilateral high-frequency continuous stimulation of the internal globus pallidus or subthalamic nucleus constitutes a new therapeutic approach for the treatment of patients with severe PD. The authors report two patients in whom stimulation of the globus pallidus failed to give long-term relief and was successfully replaced by bilateral subthalamic stimulation. The results emphasize the reversibility of deep brain stimulation therapy and suggest that the subthalamic target is preferable to the pallidal target.

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				J. Hammerstad, K. Burchiel, V. Anderson, J. Nutt, J. L. Houeto, A. M. Bonnet, B. Pidoux, D. Dormont, P. Cornu, Y. Agid, et al. Failure of long-term pallidal stimulation corrected by subthalamic stimulation in PD Neurology, August 14, 2001; 57(3): 566 - 567. [Full Text]

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