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Neurology 2000;55:820-824
© 2000 American Academy of Neurology
Articles

Serum androgens return to normal after temporal lobe epilepsy surgery in men

J. Bauer, MD, B. Stoffel-Wagner, MD, D. Flügel, MD, M. Kluge, MD, J. Schramm, MD, F. Bidlingmaier, MD and C. E. Elger, MD, FRCP

From the Departments of Epileptology (Drs. Bauer, Flügel, Kluge, and Elger), Clinical Biochemistry (Drs. Stoffel-Wagner and Bidlingmaier), and Neurosurgery (Dr. Schramm), University of Bonn, Germany

Address correspondence and reprint requests to Dr. J. Bauer, Universitätsklinik für Epileptologie, Sigmund Freud Str. 25, D-53105 Bonn, Germany; e-mail: Juergen.Bauer{at}meb.uni-bonn.de

BACKGROUND: Epileptic discharges from the temporal lobe may influence the release of hormones from the hypothalamic–pituitary axis. If epilepsy surgery influences the underlying epileptic disorder one might expect serum hormone concentrations to return to normal following surgery.

PATIENTS: Twenty-two men with epilepsy aged 25 to 48 years (mean, 34.9 years) were investigated before surgery and at 3, 6, and 12 months after surgery. Medication (all patients received carbamazepine) was maintained following surgery.

METHODS: Hormone measurements included luteinizing hormone, follicle stimulating hormone, estradiol, testosterone, free testosterone, androstenedione, prolactin, dehydroepiandrosterone sulfate, cortisol, growth hormone, and sex hormone–binding globulin. These hormone levels were compared with those of 105 healthy men (mean age, 33.9 years).

RESULTS: Fourteen of the 22 patients (63.6%) achieved total seizure control following epilepsy surgery. The 14 patients with successful seizure control entered further analysis. Before surgery these patients’ free testosterone and androstenedione concentrations were significantly lower compared with healthy men. In seven of the 14 patients a significant increase of hormone serum concentrations could be demonstrated for testosterone, free testosterone, and androstenedione. Laterality of epileptic focus, enzyme-inducing medication, stress, and the decreasing number of patients during the follow-up did not correlate with the finding of a normalization of serum androgens. Patients without complete seizure control did not show an increase in serum androgen concentrations.

CONCLUSION: Successful temporal lobe epilepsy surgery may lead to a normalization of serum androgen concentrations in men with epilepsy.




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J. Bauer, S. Blumenthal, M. Reuber, and B. Stoffel-Wagner
Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy
Neurology, January 27, 2004; 62(2): 243 - 246.
[Abstract] [Full Text] [PDF]