Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Granieri, E.
Right arrow Articles by Rosati, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Granieri, E.
Right arrow Articles by Rosati, G.
Neurology 2000;55:842-848
© 2000 American Academy of Neurology
Articles

The increasing incidence and prevalence of MS in a Sardinian province

E. Granieri, MD, I. Casetta, MD, V. Govoni, MD, M. R. Tola, MD, D. Marchi, MD, S. B. Murgia, MD, A. Ticca, MD, M. Pugliatti, MD, B. Murgia, MD and G. Rosati, MD

From the Multiple Sclerosis Center (Drs. Granieri, Casetta, Govoni, and Tola) Department of Neurology, University of Ferrara; the Section of Neurology and Neurorehabilitation (Drs. Marchi, S.B. Murgia, and Ticca), Nuoro Hospital; and the Department of Neurology, University of Sassari (Drs. Pugliatti, B. Murgia, and Rosati), Italy.

Address correspondence and reprint requests to Dr. Enrico Granieri, Clinica Neurologica, Università di Ferrara, Corso della Giovecca 203, I-44100 Ferrara, Italy; e-mail: gnr{at}dns.unife.it

OBJECTIVE: To verify incidence rates and their temporal trend in a homogeneous, ethnically, and genetically distinct population of central Sardinia (the Nuoro province).

BACKGROUND: Intensive epidemiologic studies carried out in Sardinia since the 1970s have suggested that the prevalence and incidence of MS are much higher in this Mediterranean island compared with those found on mainland Italy.

METHODS: The study area had a population of approximately 274,000 people in the 1991 census. The authors adopted a complete enumerative approach by reviewing all possible sources of case collection available in the investigative area.

RESULTS: Based on 469 MS patients, the mean annual incidence for 1955 to 1995 was 4.18 per 100,000 (or 4.3 per 100,000 if age- and sex-adjusted to the European population). The incidence, averaging 1.95 per 100,000 during 1955 to 1959, rose progressively over time, reaching rates of 6.6 in the quinquiennium 1985 to 1989 and 6.4 per 100,000 in 1990 to 1995. On December 31, 1994, the crude prevalence, based on 415 MS patients alive in the study area, was 151.9 per 100,000 (156.6 if adjusted to the European population).

CONCLUSION: These incidence and prevalence rates are the highest to date that have been estimated for a large community in southern Europe, and they constitute some of the highest rates in the world. Based on other surveys, these results reinforce the position of Sardinia as a higher and rising prevalence area for MS compared with other Mediterranean populations. Genetic and social–historic data strengthen the hypothesis of the environmental role and genetic factors among Sardinians in determining the notable difference in MS frequency between Sardinians and other Mediterraneans.




This article has been cited by other articles:


Home page
 Mult SclerHome page
E Cocco, C Sardu, R Murru, J Frau, L Lorefice, E Mamusa, P Contu, and M. Marrosu
Multiple sclerosis risk: interaction between human leukocyte antigen and the environment in Sardinian population
Multiple Sclerosis, September 1, 2009; 15(9): 1030 - 1036.
[Abstract] [PDF]

Home page
 NeurologyHome page
A. Alonso and M. A. Hernan
Temporal trends in the incidence of multiple sclerosis: A systematic review
Neurology, July 8, 2008; 71(2): 129 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
E. Granieri, C. Monaldini, R. De Gennaro, S. Guttmann, M. Volpini, M. Stumpo, P. Fazio, and I. Casetta
Multiple sclerosis in the Republic of San Marino: a prevalence and incidence study
Multiple Sclerosis, April 1, 2008; 14(3): 325 - 329.
[Abstract] [PDF]

Home page
 Mult SclerHome page
M. Debouverie, S. Pittion-Vouyovitch, S. Louis, T. Roederer, and F. Guillemin
Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France
Multiple Sclerosis, September 1, 2007; 13(8): 962 - 967.
[Abstract] [PDF]

Home page
 NeurologyHome page
D. Hirtz, D. J. Thurman, K. Gwinn-Hardy, M. Mohamed, A. R. Chaudhuri, and R. Zalutsky
How common are the "common" neurologic disorders?
Neurology, January 30, 2007; 68(5): 326 - 337.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
P. Cabre, A. Signate, S. Olindo, H. Merle, D. Caparros-Lefebvre, O. Bera, and D. Smadja
Role of return migration in the emergence of multiple sclerosis in the French West Indies
Brain, December 1, 2005; 128(12): 2899 - 2910.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Nicoletti, F. Patti, S. Lo Fermo, V. Sorbello, E. Reggio, D. Maimone, M. Zappia, and A. Reggio
Possible increasing risk of multiple sclerosis in Catania, Sicily
Neurology, October 25, 2005; 65(8): 1259 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Cocco, C. Sardu, M. Lai, G. Spinicci, P. Contu, and M.G. Marrosu
Anticipation of age at onset in multiple sclerosis: A Sardinian cohort study
Neurology, May 25, 2004; 62(10): 1794 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
F Ranzato, P Perini, E Tzintzeva, M Tiberio, M Calabrese, M Ermani, F Davetag, L De Zanche, E Garbin, F Verdelli, et al.
Increasing frequency of multiple sclerosis in Padova, Italy: a 30 year epidemiological survey
Multiple Sclerosis, August 1, 2003; 9(4): 387 - 392.
[Abstract] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G Dean, M Elian, A G. de Bono, R P. Asciak, N Vella, V Mifsud, and J Aquilina
Multiple sclerosis in Malta in 1999: an update
J. Neurol. Neurosurg. Psychiatry, September 1, 2002; 73(3): 256 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
I McDonald
Multiple sclerosis in its European matrix
Multiple Sclerosis, June 1, 2002; 8(3): 181 - 191.
[PDF]

Home page
 NeurologyHome page
M. Pugliatti, G. Solinas, S. Sotgiu, P. Castiglia, and G. Rosati
Multiple sclerosis distribution in northern Sardinia: Spatial cluster analysis of prevalence
Neurology, January 22, 2002; 58(2): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. G. Marrosu, M. Lai, E. Cocco, V. Loi, G. Spinicci, M. P. Pischedda, S. Massole, G. Marrosu, and P. Contu
Genetic factors and the founder effect explain familial MS in Sardinia
Neurology, January 22, 2002; 58(2): 283 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. G. Marrosu, R. Murru, M. R. Murru, G. Costa, P. Zavattari, M. Whalen, E. Cocco, C. Mancosu, L. Schirru, E. Solla, et al.
Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia
Hum. Mol. Genet., December 1, 2001; 10(25): 2907 - 2916.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. M.E. Grimaldi, G. Salemi, G. Grimaldi, A. Rizzo, R. Marziolo, C. Lo Presti, D. Maimone, and G. Savettieri
High incidence and increasing prevalence of MS in Enna (Sicily), southern Italy
Neurology, November 27, 2001; 57(10): 1891 - 1893.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by AAN Enterprises, Inc.