Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by He, J.
Right arrow Articles by Sanson, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by He, J.
Right arrow Articles by Sanson, M.
Neurology 2000;55:867-869
© 2000 American Academy of Neurology
Brief Communications

P18 tumor suppressor gene and progression of oligodendrogliomas to anaplasia

J. He, MD, K. Hoang-Xuan, MD, Y. Marie, MSc, P. Leuraud, MSc, K. Mokhtari, MD, M. Kujas, MD, J. Y. Delattre, MD and M. Sanson, MD, PhD

From INSERM U495 (Drs. He, Hoang-Xuan, Delattre, and Sanson, Y. Marie and P. Leuraud), the Fédération de Neurologie Mazarin (Drs. Hoang-Xuan, Delattre, and Sanson), and the Laboratory of Neuropathology "R. Escourolle" (Dr. Mokhtari), Hôpital de la Salpêtrière; and the Laboratoire d’Histologie-Embryologie-Cytogénétique (Dr. Kujas), Hôpital de la Pitié, Paris, France.

Address correspondence and reprint requests to Dr. Marc Sanson, Clinique Neurologique, Hôpital de la Salpêtrière, 47, Bd de l’Hôpital, 75013 Paris, France; e-mail: sanson{at}ccr.jussieu.fr

Article abstract—P18INK4C is a good candidate to be the tumor suppressor gene involved in oligodendrogliomas on 1p32. Loss of heterozygosity on 1p, mutation(s), homozygous deletion(s), and expression of p18 in 30 oligodendroglial tumors were investigated. Loss of heterozygosity on 1p was found in 15 tumors. A p18 mutation was found at an recurrence of an anaplastic oligodendroglioma, but not in the primary, low-grade tumor. No homozygous deletions were found and p18 was expressed in all cases. These results show that p18 alteration is involved in tumor progression in a subset of oligodendrogliomas.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
D. A. Solomon, J.-S. Kim, W. Jean, and T. Waldman
Conspirators in a Capital Crime: Co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in Glioblastoma Multiforme
Cancer Res., November 1, 2008; 68(21): 8657 - 8660.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by AAN Enterprises, Inc.