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Neurology 2000;55:870-871
© 2000 American Academy of Neurology
Brief Communications

Treatment of REM sleep behavior disorder with donepezil: A report of three cases

J. M. Ringman, MD and J. H. Simmons, MD

From the Department of Neurology (Dr. Ringman), University of California, Irvine Medical Center, Orange; and the Sadler Sleep Disorder Center (Dr. Simmons), Conroe, TX.

Address correspondence and reprint requests to Dr. Jerald Simmons, Sad-ler Clinic Sleep Disorder Center, 9201 Pinecroft Drive, The Woodlands, TX 77380; e-mail: jhsimm{at}sprynet.com

Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported. Donepezil may have a role in the treatment of REM behavior disorder, possibly through its actions on cholinergic pathways in the brainstem.




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