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Neurology 2000;55:872-874
© 2000 American Academy of Neurology
Brief Communications

Cognitive performance in surgically menopausal women on estrogen

J. Verghese, MD, G. Kuslansky, PhD, M. J. Katz, MPH, M. Sliwinski, PhD, H. A. Crystal, MD, H. Buschke, MD and R. B. Lipton, MD

From the Einstein Aging Study (Drs. Verghese, Kuslansky, Sliwinski, Crystal, Buschke, Lipton, and M. Katz), the Departments of Neurology (Drs. Verghese, Kuslansky, Sliwinski, Crystal, Buschke, Lipton, and M. Katz), and Epidemiology and Social Medicine (Dr. Lipton), Albert Einstein College of Medicine, Bronx, NY; and Innovative Medical Research (Dr. Lipton), Stamford, CT.

Address correspondence and reprint requests to Dr. Joe Verghese, Department of Neurology/Einstein Aging Study, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, NY 10461; e-mail: joev3{at}idt.net

Estrogen replacement therapy (ERT) may help maintain normal cognitive function. Nondemented surgically menopausal women on ERT (n = 10) enrolled in a longitudinal aging study performed better than age- and education-matched control subjects (n = 25) on selected tests of verbal memory and constructional ability. These results suggest that ERT initiated soon after surgical menopause can have long-term neuroprotective effects in cognitively intact women.




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