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Neurology 2000;55:875-877
© 2000 American Academy of Neurology
Brief Communications

Effect of estrogen on cerebral glucose metabolism in postmenopausal women

J. L. Eberling, PhD, B. R. Reed, PhD, J. E. Coleman, RN, MS and W. J. Jagust, MD

From the Center for Functional Imaging (Drs. Eberling, Reed, and Jagust), Lawrence Berkeley Laboratory, University of California, Berkeley; and the Department of Neurology (Drs. Eberling, Reed, and Jagust), University of California (UC) at Davis and UC Davis Alzheimer’s Disease Center (Drs. Eberling, Reed, Coleman, and Jagust), Davis, CA.

Address correspondence and reprint requests to Dr. Eberling, Center for Functional Imaging, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 55-121, Berkeley, CA 94720; e-mail: eberling{at}cfi.lbl.gov

PET was used to evaluate the effect of estrogen use on regional cerebral glucose metabolism in postmenopausal women. Women receiving estrogen replacement therapy (ERT+), women not receiving estrogen (ERT-), and women with AD were studied. The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity.




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