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Neurology 2000;55:1030-1033
© 2000 American Academy of Neurology
Brief Communications

Adult myoclonic epilepsy: A distinct syndrome of idiopathic generalized epilepsy

F. Gilliam, MD, MPH, B. J. Steinhoff, MD, H.-J. Bittermann, MD, R. Kuzniecky, MD, E. Faught, MD and B. Abou–Khalil, MD

From the Washington University Epilepsy Center (Dr. Gilliam), St. Louis, MO; Department of Clinical Neurophysiology (Drs. Steinhoff and Bittermann), Georg-August-Universitat Göttingen, Germany; University of Alabama, Birmingham (Drs. Kuzniecky and Faught); and Department of Neurology (Dr. Abou–Khalil), Vanderbilt University, Nashville, TN.

Address correspondence and reprint requests to Dr. Frank Gilliam, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110-1093.

The authors present 11 cases of idiopathic generalized epilepsy that began in adulthood at a mean age of 39 years. All patients had myoclonic jerks, five had absence seizures, and nine had infrequent generalized tonic-clonic seizures. A majority had a family history of seizures. EEG in all patients showed generalized epileptiform abnormalities, whereas neuroimaging and neurologic examination results were normal. This series appears to represent a previously undescribed idiopathic generalized epilepsy syndrome of adult myoclonic epilepsy.




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