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Neurology 2000;55:1048-1051
© 2000 American Academy of Neurology
Brief Communications

Cortical MRI findings associated with rapid correction of hyponatremia

Nicole Calakos, MD, PhD, Nancy Fischbein, MD, J. Richard Baringer, MD and Cheryl Jay, MD

From the Departments of Neurology (Drs. Calakos and Jay) and Radiology (Dr. Fischbein), University of California, San Francisco; and the Department of Neurology (Dr. Baringer), University of Utah, Salt Lake City.

Address correspondence and reprint requests to Dr. Nicole Calakos, 1001 Potrero Avenue, 4M62, Department of Neurology, San Francisco General Hospital, San Francisco, CA 94110; e-mail: calakos{at}itsa.ucsf.edu

The authors describe two patients with clinical manifestations of the osmotic demyelination syndrome (ODS) and unusual MRI findings of gadolinium-enhancing peripheral cortical abnormalities. They propose that these represent extrapontine manifestations of ODS because neither patient had a notable hypoxic–ischemic insult. Recognizing this imaging appearance is important because prognosis in ODS may be less uniformly grim than for hypoxia–ischemia.






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