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Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia?

From the Neurologische Klinik, Friedrich–Alexander–Universität Erlangen, Germany.

Address correspondence and reprint requests to Dr. Frank Birklein, Intitut für Physiologie I, Universität Erlangen, Nürnberg, Universitätsstraße 17, D-91054 Erlangen, Germany; e-mail: birklein{at}physiologie1.uni-erlangen.de

To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.

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