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Neurology 2000;55:1218-1222
© 2000 American Academy of Neurology
Brief Communications

Long-term efficacy of posteroventral pallidotomy in the treatment of Parkinson’s disease

E. C. Lai, MD, PhD, J. Jankovic, MD, J. K. Krauss, MD, W. G. Ondo, MD and R. G. Grossman, MD

From the Departments of Neurology (Drs. Lai, Jankovic, and Ondo) and Neurosurgery (Drs. Krauss and Grossman), Baylor College of Medicine, The Methodist Hospital; and Houston Veterans Affairs Medical Center (Dr. Lai), Houston, TX.

Address correspondence and reprint requests to Dr. Eugene C. Lai, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030.

The authors describe results of unilateral posteroventral pallidotomy (PVP) in 89 patients with PD. At 3 months after surgery, 81.9% of the patients reported marked or moderate improvement in their parkinsonian symptoms. Postoperative Unified PD Rating Scale "off" state mean total motor score improved by 35.5% and the mean activities of daily living score by 33.7% (p < 0.001). Improvements in parkinsonian symptoms were maintained in both "off" and "on" states in 62 patients at 12 months after PVP and in 41 patients who were followed for 18 months or longer (mean 26.6 months).




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