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Neurology 2000;55:1404-1407
© 2000 American Academy of Neurology
Brief Communications

Restless legs syndrome in monozygotic twins: Clinical correlates

William G. Ondo, MD, Kevin Dat Vuong, MA and Qing Wang, PhD

From the Parkinson’s Disease Center and Movement Disorders Clinic (Dr. Ondo and K.D. Vuong), Department of Neurology, Baylor College of Medicine, Houston, TX; and the Center for Molecular Genetics, Department of Molecular Cardiology, and Department of Cardiology (Dr. Wang), The Cleveland Clinic Foundation, Cleveland, OH.

Address correspondence and reprint requests to Dr. William Ondo, 6550 Fannin Dr., Suite 1801, Houston, TX 77030; e-mail: wondo{at}bcm.tmc.edu

Article abstract—To better understand genetic characteristics of restless legs syndrome (RLS) and identify nongenetic factors that may influence phenotype, the authors studied 12 identical twins in which at least one member expressed RLS. Ten of the 12 twin pairs were concordant for RLS symptoms. Despite the high concordance rate, the disease severity, age at onset, and symptom descriptions often varied between twins. Birth order, birth weight, and serum ferritin levels did not predict RLS severity or age at onset.




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