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From the Department of Neurology (Drs. Albin, Chervin, Consens, Wernette, Frey, and Aldrich), University of Michigan; the Geriatrics Research, Education, and Clinical Center (Dr. Albin), Ann Arbor VAMC; and the Division of Nuclear Medicine, Department of Radiology (Drs. Koeppe, Wernette, and Frey), University of Michigan, Ann Arbor.
Address correspondence and reprint requests to Dr. Roger L. Albin, Neuroscience Laboratory Building, 1103 E. Huron, Ann Arbor, MI, 48104-1687; e-mail: ralbin{at}umich.edu
Article abstract—REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.
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