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Neurology 2001;56:104-106
© 2001 American Academy of Neurology


Brief Communications

HTLV-1–associated myelopathy/tropical spastic paraparesis with pseudohypoparathyroidism

Naoko Machigashira, MD;, Yoshihiro Yoshida, MD;, Sha-yan Wang, MD and Mitsuhiro Osame, MD

From the Third Department of Internal Medicine (Drs. Machigashira, Wang, and Osame), School of Medical Sciences (Dr. Yoshida), Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan.

Address correspondence and reprint requests to Dr. Yoshihiro Yoshida, School of Medical Sciences, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8506, Japan; e-mail: yoshiday{at}health.nop.kagoshima-u.ac.jp

In many short-stature patients with human T-lymphotrophic virus type I–associated myelopathy/tropical spastic paraparesis (HAM/TSP), signs and symptoms were manifested during childhood. Successive investigations revealed 12 of 14 short-stature patients with pseudohypoparathyroidism (PHP) from the findings of short metacarpi, parathyroid hormone infusion test, immunoblotting of erythrocyte membrane, or lymphocytic Northern blotting of Gs{alpha}. Patients with PHP probably showed HAM/TSP based on their modified immunologic status. Human T-lymphotrophic virus type I infection did not induce PHP, but PHP may be a risk factor for the occurrence of HAM/TSP.




This article has been cited by other articles:


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NeurologyHome page
R. Fritzen, A. Dressel, and Y. Yoshida
HTLV-I associated myelopathy/tropical spastic paraparesis with pseudohypothyroidism
Neurology, October 9, 2001; 57(7): 1349 - 1350.
[Full Text] [PDF]

Correspondence:

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HTLV-1–associated myelopathy/tropical spastic paraparesis with pseudohypoparathyroidism
Reimar Fritzen, et al.
Neurology Online, 10 Jun 2001 [Full text]
Reply to Fritzen and Dressel
Yoshihiro Yoshida, et al.
Neurology Online, 10 Jun 2001 [Full text]



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