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Neurology 2001;56:112-115
© 2001 American Academy of Neurology
Brief Communications

Clinical and spectroscopic improvement in HIV-associated cognitive impairment

B. Stankoff, MD*;, A. Tourbah, MD, PhD*;, S. Suarez, PhD;, E. Turell, MD;, J.L. Stievenart, MD;, C. Payan, MD, PhD;, A. Coutellier, MD;, S. Herson, MD;, L. Baril, MD;, F. Bricaire, MD;, V. Calvez, MD, PhD;, E.A. Cabanis, MD;, L. Lacomblez, MD, PhD and C. Lubetzki, MD, PhD

From the Fédération de Neurologie I (Drs. Stankoff, Tourbah, Turell, and Lubetzki), Laboratoire de Neuropathologie R. Escourolle (Dr. Suarez), Fédération de Neurologie Mazarin II (Dr. Lacomblez), and Service de Pharmacologie (Drs. Payan and Lacomblez,), Service de Médecine Interne (Drs. Coutellier and Herson); Service des Maladies Infectieuses (Drs. Baril and Bricaire), Laboratoire de Virologie CERVI (Dr. Calvez), Hôpital Pitié Salpêtrière, AP-HP and University Paris VI; and Service de Neuroradiologie (Drs. Tourbah, Stievenart, and Cabanis), Centre Hospitalier National des Quinze-Vingts, Paris, France.

Address correspondence and reprint requests to Prof. C. Lubetzki, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Bld de l’Hôpital, 75651 Paris Cedex 13, France; e-mail: catherine.lubetzki{at}psl.ap-hop-paris.fr

To assess the impact of highly active antiretroviral therapy (HAART) on AIDS-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS every 3 months for 9 months. Nineteen patients were on HAART at study entry, 21 after 2 months. Cognitively impaired patients presented with a subcorticofrontal deficit and decreased N-acetyl-aspartate in frontal white matter. These clinical and metabolic abnormalities reversed partially on HAART, whereas they remained within normal limits in cognitively unimpaired patients.




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