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From Neuroimaging Research Unit (Drs. Rocca, Filippi, and Sormani), Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy; and Departments of Neurology (Drs. Herzog and Dichgans) and Neuroradiology (Dr. Yousry), Klinikum Grosshadern, Munich, Germany.
Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy; e-mail address: m.filippi{at}hsr.it
The authors obtained MR and magnetization transfer (MT) imaging of the cervical cord from 25 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). They found no conventional MR abnormalities, but a reduced peak height of the MT ratio (MTR) histogram. This suggests a reduced amount of "truly" normal cord tissue in CADASIL. A significant correlation was found between the extent of brain lesions and cord MTR, suggesting wallerian degeneration as the substrate of the cord MTR changes.
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