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From the Department of Neurology (Drs. Stiasny and Oertel), Center of Nervous Diseases, Philipps University of Marburg; Max Planck Institute of Psychiatry (Drs. Wetter, Winkelmann, and Trenkwalder), Munich; Department of Internal Medicine (Drs. Brandenburg and Penzel), Philipps University of Marburg; and Lilly Deutschland GmbH (Drs. Rubin and Hundemer), Bad Homburg, Germany.
Address correspondence and reprint requests to Dr. Karin Stiasny, Department of Neurology, Center of Nervous Diseases, Rudolf-Bultmann-Strasse 8, D-35033 Marburg, Germany; e-mail: stiasny{at}mailer.uni-marburg.de
An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
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