HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) CME: Take the course for this article: Volume 56, Number 10, May 22, 2001 Supplementary Data Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bohan, T. P. Articles by Koch, G. Search for Related Content PubMed PubMed Citation Articles by Bohan, T. P. Articles by Koch, G. Related Collections All Epilepsy/Seizures

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

From the Department of Pediatrics (Dr. Bohan, I. McDonald, and S. Gazitt), University of Texas Medical School, Houston; Hermann Children’s Hospital (Dr. Bohan), Houston, TX; SAS Institute (Dr. Helton), Cary, NC; Children’s Hospitals (Dr. Konig), University of Mannheim, Germany; Kansai Medical University (Dr. Sugimoto), Otokoama Hospital, Kyoto, Japan; Virchow Hospital (Dr. Scheffner), Humboldt University, Berlin, Germany; and the University of North Carolina (Dr. Koch, L. Cusmano, and S. Li), Chapel Hill.

Address correspondence and reprint requests to Dr. T.P. Bohan, Therapeutics Research, 1213 Hermann Drive, Houston, TX 77004; e-mail: tpbohan{at}aol.com

The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survived (p < 0.001). Early intervention with IV rather than enteral L-carnitine was associated with the greatest hepatic survival. Specifically, all 10 patients who were diagnosed in <5 days and treated with IV L-carnitine survived. Most patients had features of chronic illness and most children appeared to be malnourished.

This article has been cited by other articles:

				Y. Chan, M. Tse, and F. Lau Two cases of valproic acid poisoning treated with l-carnitine Human and Experimental Toxicology, December 1, 2007; 26(12): 967 - 969. [Abstract] [PDF]

				J. Wadzinski, R. Franks, D. Roane, and M. Bayard Valproate-associated Hyperammonemic Encephalopathy J Am Board Fam Med, September 1, 2007; 20(5): 499 - 502. [Abstract] [Full Text] [PDF]

				W. Sanchez, J. T. Maple, L. J. Burgart, and P. S. Kamath Severe Hepatotoxicity Associated With Use of a Dietary Supplement Containing Usnic Acid Mayo Clin. Proc., April 1, 2006; 81(4): 541 - 544. [Abstract] [Full Text] [PDF]

				D. C. DeVivo, T. P. Bohan, S. A. Konig, T. Sugimota, and E. Helton Effect of L-carnitine treatment for valproate-induced hepatotoxicity Neurology, February 12, 2002; 58(3): 507 - 508. [Full Text] [PDF]

Correspondence: