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 Volume 56, Number 10, May 22, 2001
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Neurology 2001;56:1405-1409
© 2001 American Academy of Neurology
Brief Communications

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

T. P. Bohan, PhD, MD;, E. Helton, PhD;, I. McDonald, S. König, MD;, S. Gazitt, MA;, T. Sugimoto, PhD, MD;, D. Scheffner, MD;, L. Cusmano, MS;, S. Li, MS; and G. Koch, PhD

From the Department of Pediatrics (Dr. Bohan, I. McDonald, and S. Gazitt), University of Texas Medical School, Houston; Hermann Children’s Hospital (Dr. Bohan), Houston, TX; SAS Institute (Dr. Helton), Cary, NC; Children’s Hospitals (Dr. Konig), University of Mannheim, Germany; Kansai Medical University (Dr. Sugimoto), Otokoama Hospital, Kyoto, Japan; Virchow Hospital (Dr. Scheffner), Humboldt University, Berlin, Germany; and the University of North Carolina (Dr. Koch, L. Cusmano, and S. Li), Chapel Hill.

Address correspondence and reprint requests to Dr. T.P. Bohan, Therapeutics Research, 1213 Hermann Drive, Houston, TX 77004; e-mail: tpbohan{at}aol.com

The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survived (p < 0.001). Early intervention with IV rather than enteral L-carnitine was associated with the greatest hepatic survival. Specifically, all 10 patients who were diagnosed in <5 days and treated with IV L-carnitine survived. Most patients had features of chronic illness and most children appeared to be malnourished.




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Correspondence:

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Effect of L-carnitine treatment for valproate-induced hepatotoxicity
Darryl C De Vivo
Neurology Online, 16 Oct 2001 [Full text]
Reply to Dr DeVivo
Timothy Bohan
Neurology Online, 16 Oct 2001 [Full text]

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