| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Neuropsychology Laboratory (A. Collie, Dr. Maruff, R. Shafiq-Antonacci, and Dr. Currie) and Neuropathology Research Unit (M. Smith and Dr. Masters), Mental Health Research Institute of Victoria, Parkville; School of Psychological Sciences (A. Collie and Dr. Maruff), La Trobe University, Bundoora, Victoria; the Department of Pathology (R. Shafiq-Antonacci, M. Smith, and Dr. Masters), The University of Melbourne, Parkville, Victoria; The Garvan Institute of Medical Research (M. Hallup and Dr. Schofield), Sydney, New South Wales; and the Brain Research Unit (Dr. Currie), Westmead Hospital, Westmead, New South Wales, Australia.
Address correspondence and reprint requests to Mr. Alexander Collie, Neuropsychology Laboratory, Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, Victoria, 3052, Australia; e-mail: alex{at}neuro.mhri.edu.au
Background: Criteria for mild cognitive impairment require objective evidence of a memory deficit but do not require objective evidence of memory decline. Application of these criteria may therefore result in the misclassification of older patients with memory decline as normal because their neuropsychological test performance at a single point in time may be within normal limits. This study aimed to identify and characterize older people with memory decline. Method: Word list delayed recall (WLDR) test performance was assessed on five occasions during a 2-year period in a cohort of healthy older individuals. Older people with declining (n = 35) and nondeclining (n = 66) WLDR scores were identified. Both subgroups were then compared on apoE genotype, Clinical Dementia Rating, and neuropsychological test performance at the fifth assessment. Results: Thirty-four percent of the group with declining memory recorded a Clinical Dementia Rating of 0.5, compared with 5% of the nondeclining memory group. No between-group differences were observed in cognitive domains other than memory, self-reported cognitive failures, or the proportion of each group carrying the apoE epsilon 4 allele. Conclusions: A large proportion of healthy older individuals show memory decline, which may represent the early stages of a potentially more severe cognitive impairment. Further investigation is necessary to determine the relationship between apoE genotype, self-reported cognitive impairment, and memory decline in older people.
This article has been cited by other articles:
|
|
 |
|
  C. A. de Jager, A.-C. M. C. Schrijnemaekers, T. E. M. Honey, and M. M. Budge Detection of MCI in the clinic: evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE Age Ageing, July 1, 2009; 38(4): 455 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Maruff, E. Thomas, L. Cysique, B. Brew, A. Collie, P. Snyder, and R. H. Pietrzak Validity of the CogState Brief Battery: Relationship to Standardized Tests and Sensitivity to Cognitive Impairment in Mild Traumatic Brain Injury, Schizophrenia, and AIDS Dementia Complex Arch Clin Neuropsychol, March 25, 2009; (2009) acp010v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Zehnder, S. Blasi, M. Berres, R. Spiegel, and A. U. Monsch Lack of Practice Effects on Neuropsychological Tests as Early Cognitive Markers of Alzheimer Disease? American Journal of Alzheimer's Disease and Other Dementias, November 1, 2007; 22(5): 416 - 426. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Pfennig, E. Littmann, and M. Bauer Neurocognitive Impairment and Dementia in Mood Disorders J Neuropsychiatry Clin Neurosci, November 1, 2007; 19(4): 373 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kalaydjian, P. P. Zandi, K. L. Swartz, W. W. Eaton, and C. Lyketsos How migraines impact cognitive function: Findings from the Baltimore ECA Neurology, April 24, 2007; 68(17): 1417 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marcos, P. Gil, A. Barabash, R. Rodriguez, M. Encinas, C. Fernandez, and J. A. Cabranes Neuropsychological Markers of Progression From Mild Cognitive Impairment to Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, May 1, 2006; 21(3): 189 - 196. [Abstract] [PDF]
|
|
|
|
 |
|
 G. E. Swan, C. N. Lessov-Schlaggar, D. Carmelli, G. D. Schellenberg, and A. La Rue Apolipoprotein E {epsilon}4 and Change in Cognitive Functioning in Community-Dwelling Older Adults J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 196 - 201. [Abstract] [PDF]
|
|
|
|
|
|
C. K. Blair, A. R. Folsom, D. S. Knopman, M. S. Bray, T. H. Mosley, E. Boerwinkle, and for the Atherosclerosis Risk in Communities Study APOE genotype and cognitive decline in a middle-aged cohort Neurology, January 25, 2005; 64(2): 268 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Clark and J. H.T. Karlawish Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies Ann Intern Med, March 4, 2003; 138(5): 400 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lamar, S. M. Resnick, and A. B. Zonderman Longitudinal changes in verbal memory in older adults: Distinguishing the effects of age from repeat testing Neurology, January 14, 2003; 60(1): 82 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Darby, P. Maruff, A. Collie, and M. McStephen Mild cognitive impairment can be detected by multiple assessments in a single day Neurology, October 8, 2002; 59(7): 1042 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Collie, D Darby, and P Maruff Computerised cognitive assessment of athletes with sports related head injury Br. J. Sports Med., October 1, 2001; 35(5): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
