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Large-fiber neuropathy in distal sensory neuropathy with normal routine nerve conduction

From the Department of Neurology, University of Alabama at Birmingham, The Veterans Affairs Medical Centre.

Address correspondence and reprint requests to Dr. Shin J. Oh, Department of Neurology, The University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294; e-mail: shinjoh{at}uab.edu

Near-nerve needle sensory nerve conduction of plantar nerves in 100 patients with distal sensory neuropathy with normal routine nerve conduction (DSN-NNC) found the definite neuropathy pattern (abnormality in more than three of six tested nerves) in 65%, axonal neuropathy in 35%, and the known cause in 37% of patients. Absent or diminished reflexes were a reliable indicator for large fiber neuropathy (LFN). This near-nerve needle plantar nerve study provides useful and unequivocal evidence of its value in identifying neuropathy in DSN-NNC by finding LFN in 65% of patients.

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