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Neurology 2001;56:1582-1584
© 2001 American Academy of Neurology
Brief Communications

Thrombolysis of extracranial and intracranial arteries after IV abciximab

E. Houdart, MD;, F. Woimant, MD;, R. Chapot, MD;, C. Mounayer, MD;, C. Soria, MD, PhD; and J.–J. Merland, MD, PhD

From the Departments of Neuroradiology and Therapeutic Angiography (Drs. Houdart, Chapot, and Mounayer), Neurology (Dr. Woimant), and Hematology (Dr. Soria), Hôpital Lariboisière, Paris, France.

Address correspondence and reprint requests to Dr. Emmanuel Houdart, Service de Neuroradiologie et d’Angiographie Thérapeutique, Hôpital Lariboisière, 2 rue Ambroise Paré, 75010 Paris, France; e-mail: ehoudart{at}compuserve.com

Abciximab was administered intravenously to three patients to treat thrombus associated with atherosclerotic stenosis of a supra-aortic artery. In two cases, the thrombi had been identified on a previous angiography more than a week before treatment. Successful thrombolysis was achieved with abciximab in all three cases. In this small series, abciximab had a thrombolytic effect on established thrombi that were refractory to previous antithrombotic treatment attempts.




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