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Neurology 2001;56:1593-1595
© 2001 American Academy of Neurology
Brief Communications

The angiotensin I converting enzyme gene as a susceptibility factor for dementia

F. Richard, MD, PhD;, I. Fromentin–David, MD;, F. Ricolfi, MD;, P. Ducimetière, PhD;, C. Di Menza, MD;, P. Amouyel, MD, PhD; and N. Helbecque, PhD

From INSERM Unité 508 (Drs. Richard, Amouyel, and Helbecque), Institut Pasteur de Lille; Service de Gérontologie Clinique (Drs. Fromentin–David and Di Menza), Centre Hospitalier Emile Roux, Assistance Publique–Hôpitaux de Paris, Limeil Brévannes; Service de Neuroradiologie (Dr. Ricolfi), Centre Hospitalier Henri Mondor, Créteil, Assistance Publique–Hôpitaux de Paris, Créteil; and INSERM Unité 258 (Dr. Ducimetière), Hôpital Paul Brousse, Villejuif Cedex, France.

Address correspondence and reprint requests to Dr. Philippe Amouyel, INSERM Unité 508, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France; e-mail: philippe.amouyel{at}pasteur-lille.fr

The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case–control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.




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