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Neurology 2001;56:1759-1762
© 2001 American Academy of Neurology
Brief Communications

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

A.T. Portman, MD;, N. Giladi, MD;, K.L. Leenders, PhD;, P. Maguire, PhD;, L. Veenma–van der Duin, J. Swart, J. Pruim, PhD;, E.S. Simon, MD;, S. Hassin–Baer, MD; and A.D. Korczyn, PhD

From the Movement Disorder Unit (Drs. Portman, Leenders, and Maguire and L. Veenma–van der Duin and J. Swart), Department of Neurology, University Hospital, Groningen, the Netherlands; the Movement Disorder Unit (Drs. Giladi, Simon, and Hassin–Baer), Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel; PET Center (Dr. Pruim), University Hospital, Groningen, the Netherlands; Sieratzki Chair of Neurology (Dr. Korczyn), Tel-Aviv University Medical School, Ramat-Aviv, Israel.

Address correspondence and reprint requests to Prof. Dr. K.L. Leenders, Groningen University Hospital, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, the Netherlands; e-mail: k.l.leenders{at}neuro.azg.nl

Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.




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