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Neurology 2001;56:248-250
© 2001 American Academy of Neurology
Brief Communications

Positive response to immunomodulatory therapy in an adult patient with Rasmussen’s encephalitis

F. Villani, MD, R. Spreafico, MD, L. Farina, MD, A.R. Giovagnoli, MD, P. Bernasconi, PhD, T. Granata, MD and G. Avanzini, MD

From the Division of Clinical Neurophysiology and Epileptology (Drs. Villani, Spreafico, and Avanzini), Division of Neuroradiology (Dr. Farina), Service of Neuropsychology (Dr. Giovagnoli), Laboratory of Neuroimmunology (Dr. Bernasconi), and Division of Pediatric Neurology (Dr. Granata), Istituto Nazionale Neurologico "C. Besta," Milan, Italy.

Address correspondence and reprint requests to Dr. Flavio Villani, Division of Clinical Neurophysiology and Epileptology, Istituto Nazionale Neurologico "C. Besta", Via Celoria 11, 20133 Milan, Italy; e-mail: neurofisiologia{at}istituto-besta.it

Rasmussen’s encephalitis (RE) is a rare and progressive neurologic condition of uncertain etiology that typically has a childhood onset. The authors describe a 45-year-old woman with adult-onset progressive aphasia, right hemiparesis, severe drug refractory epilepsy, and left cerebral hemisphere atrophy. High-dose corticosteroids and plasmapheresis were not effective. She improved with high-dose therapy with human IV immunoglobulin.




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