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From Department of Neurology at Johns Hopkins Bayview Medical Center and Hopkins Sleep Disorders Center (Drs. Allen and Earley) and Department of Radiology (Dr. Barker), Johns Hopkins University School of Medicine, Baltimore, MD; and Department of Radiology (Drs. Wehrl and Song), University of Pennsylvania School of Medicine, Philadelphia.
Address correspondence and reprint requests to Dr. Richard P. Allen, Johns Hopkins Bayview Medical Center, Department of Neurology, Sleep Disorders, A Bldg., 6C room 678, 4940 Eastern Ave., Baltimore, MD 21224; e-mail: richardjhu{at}aol.com
Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.
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