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Neurology 2001;56:270-272
© 2001 American Academy of Neurology
Brief Communications

Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis

C. Ferrarese, MD, PhD;, G. Sala, PhD, R. Riva, MD, B. Begni, PhD, C. Zoia, PhD, L. Tremolizzo, MD, G. Galimberti, PhD, A. Millul, MD, A. Bastone, PhD, T. Mennini, PhD, C. Balzarini, MD, L. Frattola, MD, E. Beghi, MD and the Italian ALS Study Group*

From the Department of Neurosciences and Biomedical Technologies (Drs. Ferrarese, Sala, Riva, Begni, Zoia, Tremolizzo, Galimberti, Millul, Frattola, and Beghi), University of Milano–Bicocca, Ospedale San Gerardo, Monza; Department of Molecular Biochemistry and Pharmacology (Drs. Bastone and Mennini), "Mario Negri" Institute for Pharmacological Research, Milan; and the "S. Maugeri" Foundation (Dr. Balzarini), Veruno, No, Italy.

Address correspondence and reprint requests to Prof. Carlo Ferrarese, Department of Neurology, University of Milano–Bicocca, San Gerardo Hospital, via Donizetti, 106-20052 Monza (MI), Italy; e-mail: carlo.ferrarese{at}unimib.it

Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.




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C. N. Morrell, H. Sun, M. Ikeda, J.-C. Beique, A. M. Swaim, E. Mason, T. V. Martin, L. E. Thompson, O. Gozen, D. Ampagoomian, et al.
Glutamate mediates platelet activation through the AMPA receptor
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