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Neurology 2001;56:388-391
© 2001 American Academy of Neurology
Brief Communications

Reversible posterior leukoencephalopathy during the treatment of acute lymphoblastic leukemia

R.K. Shin, MD;, J.W. Stern, MD;, A.J. Janss, MD, PhD;, J.V. Hunter, MD; and G.T. Liu, MD

From the Division of Hematology/Oncology (Drs. Stern and Janss) and Neuroradiology (Dr. Hunter) and Neuro-ophthalmology (Drs. Shin and Liu) Services, Children’s Hospital of Philadelphia, PA.

Address correspondence and reprint requests to Dr. G.T. Liu, Division of Neuro-ophthalmology, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104-4283; e-mail: gliu{at}mail.med.upenn.edu

Three children with acute lymphoblastic leukemia developed altered mental status, headaches, seizures, and visual changes associated with reversible posterior cerebral changes on MRI. These clinical and radiologic findings were consistent with the reversible posterior leukoencephalopathy syndrome, which has not been widely recognized in this setting.




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