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Neurology 2001;56:415-418
© 2001 American Academy of Neurology
Brief Communications

Clinical trials in HIV-associated cognitive impairment: Cognitive and functional outcomes

G. Schifitto, MD;, K. Kieburtz, MD, MPH;, M.P. McDermott, PhD;, J. McArthur, MB, BS, MPH;, K. Marder, MD, MPH;, N. Sacktor, MD;, D. Palumbo, PhD;, O. Selnes, PhD;, Y. Stern, PhD;, L. Epstein, MD; and S. Albert, PhD

From the Departments of Neurology (Drs. Schifitto, Kieburtz, and Palumbo) and Biostatistics (Dr. McDermott), University of Rochester, NY; Department of Neurology (Drs. McArthur, Sacktor, and Selnes), Johns Hopkins University, Baltimore, MD; Department of Neurology (Drs. Marder, Stern, and Albert), Columbia University, New York; and Department of Neurology (Dr. Epstein), Northwestern University, Chicago, IL.

Address correspondence and reprint requests to Dr. G. Schifitto, Department of Neurology, University of Rochester, 601 Elmwood Avenue, Box 673, Rochester, NY 14642.

Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.




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